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KMID : 1137020180290010016
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Journal of Gynecologic Oncology
2018 Volume.29 No. 1 p.16 ~ p.16
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Survival benefit of patients with early-stage ovarian carcinoma treated with paclitaxel chemotherapeutic regimens
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Chen Chien An
Chiang Chun Ju
Chen Yun Yuan
You San Lin
Hsieh Shu Feng
Tang Chao Hsiun
Cheng Wen Fang
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Abstract
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Objective: Adjuvant chemotherapy was introduced in patients with early-stage ovarian cancer (OC). The benefit of standard chemotherapeutic regimens including taxane has not been established.
Methods: Patients with early-stage OC from the National Health Insurance Research database of Taiwan who received platinum plus cyclophosphamide (CP) or platinum plus paclitaxel (PT) for 3?6 cycles were recruited, and the disease-free survival (DFS) and overall survival (OS) were determined.
Results: A total of 1,510 early-stage OC patients, including 841 who received CP regimen and 699 who received PT regimen, were included. The 2 groups had a similar estimated probability of 5-year DFS (PT vs. CP, 79.0% vs. 77.6%; p=0.410) and OS (84.6% vs. 84.3%; p=0.691). Patients >50 years of age who received the CP regimen had a lower 5-year DFS than the patients ≤50 years of age who received the CP (p<0.001) or PT regimens (p=0.001). Additionally, patients >50 years of age who received the CP regimen had a worse 5-year OS compared with the other 3 groups (p=0.019) (p=0.179 for patients >50 years of age in the PT group; p=0.002 for patients ≤50 years of age in the CP group; and p=0.061 for patients ≤50 years of age in the PT group). Patients with the CP or PT regimen for 3?5 cycles had a similar 5-year DFS and OS compared to 6 cycles (p>0.050).
Conclusion: Chemotherapeutic regimens with taxane could be recommended for early-stage OC patients >50 years of age.
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KEYWORD
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Ovarian Neoplasms, Drug Therapy, Taxane, Disease-Free Survival, Survival
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